Journal
THERANOSTICS
Volume 1, Issue -, Pages 240-250Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno/v01p0240
Keywords
Photodynamic therapy; Graphene oxide; Folic acid; Chlorin e6; Drug delivery
Categories
Funding
- National Key Basic Research Program (973 Project) [2010CB933901]
- National 863 Hi-tech Project [2007AA022004]
- Important National Science & Technology Specific Projects [2009ZX10004-311]
- National Natural Scientific Fund [20803040]
- Special project for nano-technology from Shanghai [1052nm04100]
- New Century Excellent Talent of Ministry of Education of China [NCET-08-0350]
- Shanghai Science and Technology Fund [10XD1406100]
- Shanghai Jiao Tong University
Ask authors/readers for more resources
Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and p-p stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available