Journal
STEM CELL RESEARCH & THERAPY
Volume 4, Issue -, Pages -Publisher
BMC
DOI: 10.1186/scrt381
Keywords
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Funding
- General Research Fund [HKU 7801/10 M, HKU 7811/11 M, HKU 7795/12 M]
- Collaborative Research Fund [HKU 8/CRF/09]
- Theme-based Research Scheme of the Research Grant Council of Hong Kong [T12-705/11]
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Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the permanent loss of cardiomyocytes after the insult, which contributes to progressive pathological left ventricular remodeling and progressive heart failure. As a result, cell-based therapies using multipotent (adult) stem cells and pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells) have been explored as potential therapeutic approaches to restore cardiac function in heart failure. Nevertheless, the optimal cell type with the best therapeutic efficacy and safety for heart regeneration is still unknown. In this review, the potential pros and cons of different types of multipotent (adult) stem cells and pluripotent stem cells that have been investigated in preclinical and clinical studies are reviewed, and the future perspective of stem cell-based therapy for heart regeneration is discussed.
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