Journal
STANDARDS IN GENOMIC SCIENCES
Volume 4, Issue 2, Pages 244-251Publisher
BMC
DOI: 10.4056/sigs.1223234
Keywords
Institute for Genome Sciences; functional annotation; structural annotation; microbial genomics; prokaryotic genomics; annotation pipeline; pFunc; Glimmer; HMM; BER; Ergatis; Manatee; IGS Annotation Engine
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Funding
- National Institute of General Medical Sciences, National Institutes of Health [5R01GM080227-05]
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The Institute for Genome Sciences (IGS) has developed a prokaryotic annotation pipeline that is used for coding gene/RNA prediction and functional annotation of Bacteria and Archaea. The fully automated pipeline accepts one or many genomic sequences as input and produces output in a variety of standard formats. Functional annotation is primarily based on similarity searches and motif finding combined with a hierarchical rule based annotation system. The output annotations can also be loaded into a relational database and accessed through visualization tools.
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