Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-018-33214-3
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Funding
- National Natural Science Foundation of China [81573094]
- Natural Science Foundation of Tianjin [15JCZDJC35200]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2017-I2M-3-019]
- Tianjin science and technology project [13ZXCXSY13500]
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Radiation enteritis is an old but emerging question induced by the application of radiation. However, no effective drugs for radiation enteritis in clinic. In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. After exposure to irradiation, TQ-treated improved the irradiated mice survival rate, ameliorated intestinal injury and increased the numbers of intestinal crypts. Furthermore, Lgr5(+) ISCs and their daughter cells, including Vil1(+) enterocytes, Ki67(+) cells and lysozyme(+) Paneth cells, were all significantly increased with TQ treatment. In addition, P53, gamma H2AX, caspase8, caspase9 and caspase3 expression were all reduced by TQ. Our data showed that TQ modulated DNA damages and decreased the apoptosis in the small intestine. TQ might be used for radiation enteritis treatment.
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