Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-34423-6
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Funding
- Sao Paulo Research Foundation (FAPESP) [2013/21719-3, 2016/15021-1, 2015/12295-0, 2014/23159-8]
- CNPq [440593/2016-6]
- INCT-Dengue
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES/Finance) [001]
- NIH [1U01AI115577]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI115577] Funding Source: NIH RePORTER
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In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NH P ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
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