Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-14121-5
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Funding
- National Research Council of Thailand
- Health Systems Research Institute (HSRI)
- Ratchadapiseksompotch Endowment Fund Part of the Research Grant for New Scholar CU Researcher's Project [RGN_2557_008_02_30]
- Ratchadapiseksompotch Endowment Funds [RA60/018]
- Graduate school, Chulalongkorn University
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Dengue virus infection is a global threat for which no specific treatment has not been established. Previous reports suggested chrysin and flavanone derivatives were potential flaviviral inhibitors. Here, we reported two halogenated chrysins, abbreviated FV13 and FV14, were highly potent against DENV1-4 and ZIKV infectivities with the FV13 EC50 values of 2.30 +/- 1.04, 1.47 +/- 0.86, 2.32 +/- 1.46, 1.78 +/- 0.72 and 1.65 +/- 0.86 mu M; and FV14 EC50 values of 2.30 +/- 0.92, 2.19 +/- 0.31, 1.02 +/- 0.31, 1.29 +/- 0.60 and 1.39 +/- 0.11 mu M, respectively. The CC(50)s to LLC/MK2 of FV13 and FV14 were 44.28 +/- 2.90 mu M, 42.51 +/- 2.53 mu M, respectively. Mechanism of drug action studies suggested multiple targets but maximal efficiency was achieved with early post infection treatment. This is the first report showing a high potency of halogenated chrysins for development as a broad-spectrum anti-flaviviral drug.
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