4.7 Article

Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

Journal

SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41598-017-16391-5

Keywords

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Funding

  1. Trinity College Dublin, Dublin, Ireland (European Commission H2020) [633666]
  2. Italian Institute for Genomic Medicine (IIGM), Torino, Italy
  3. Compagnia di San Paolo
  4. Swiss National Science Foundation (Ambizione) [PZ00P3_147998]
  5. Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme
  6. European Union [226756]
  7. UK Medical Research Council [K013351]
  8. NordForsk
  9. Australian National Health and Medical Research Council [1011618, 1026892, 1026522, 1050198, 623206, 1043616, 209057, 1074383]
  10. MRC [MR/K013351/1, MR/M501669/1] Funding Source: UKRI
  11. Swiss National Science Foundation (SNF) [PZ00P3_147998] Funding Source: Swiss National Science Foundation (SNF)
  12. Medical Research Council [MR/M501669/1, MR/K013351/1] Funding Source: researchfish

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Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (beta = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social

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