Related references
Note: Only part of the references are listed.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
Erkin Erdal et al.
GENES & DEVELOPMENT (2017)
'Hints' in the horn: diagnostic clues in the stratum corneum
Jose Carlos Cardoso et al.
JOURNAL OF CUTANEOUS PATHOLOGY (2017)
The Molecular Revolution in Cutaneous Biology: Chromosomal Territories, Higher-Order Chromatin Remodeling, and the Control of Gene Expression in Keratinocytes
Vladimir A. Botchkarev
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)
Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death
Heinz Fischer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)
Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus
Benedikt Scholtissek et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)
Coupling organelle inheritance with mitosis to balance growth and differentiation
Amma Asare et al.
SCIENCE (2017)
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis
Heinz Fischer et al.
SCIENTIFIC REPORTS (2017)
Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity
Vanja Sisirak et al.
CELL (2016)
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Axel Roers et al.
IMMUNITY (2016)
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
Katrin Peschke et al.
JOURNAL OF IMMUNOLOGY (2016)
The Exonuclease Trex2 Shapes Psoriatic Phenotype
Joan Manils et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)
Innate Antiviral Defenses Independent of Inducible IFNα/β Production
Soren R. Paludan
TRENDS IN IMMUNOLOGY (2016)
Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1
Yanick J. Crow et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2015)
AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation
A. S. Naeem et al.
CELL DEATH AND DIFFERENTIATION (2015)
Activation and Regulation of DNA-Driven Immune Responses
Soren R. Paludan
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2015)
DNase II-dependent DNA digestion is required for DNA sensing by TLR9
Mei Po Chan et al.
NATURE COMMUNICATIONS (2015)
Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis
Joan Manils et al.
ONCOTARGET (2015)
Mesotrypsin and Caspase-14 Participate in Prosaposin Processing POTENTIAL RELEVANCE TO EPIDERMAL PERMEABILITY BARRIER FORMATION
Mami Yamamoto-Tanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA
Srikanth Chiliveru et al.
JOURNAL OF IMMUNOLOGY (2014)
Deregulated Type I IFN Response in TREX1-Associated Familial Chilblain Lupus
Katrin Peschke et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia
C. Saiz-Ladera et al.
ONCOGENE (2014)
DNA Degradation and Its Defects
Kohki Kawane et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation
M. Yamamoto-Tanaka et al.
CELL DEATH & DISEASE (2014)
In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease
Martine Aubert et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2014)
Mechanisms regulating skin immunity and inflammation
Manolis Pasparakis et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Cell death by cornification
Leopold Eckhart et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
Nadine Gehrke et al.
IMMUNITY (2013)
Parakeratotic Corneocytes Play a Unique Role in Human Skin Wound Healing
Marcia L. Usui et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Remodeling of Three-Dimensional Organization of the Nucleus during Terminal Keratinocyte Differentiation in the Epidermis
Michal R. Gdula et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Caspase-14-Deficient Mice Are More Prone to the Development of Parakeratosis
Esther Hoste et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption
Michael T. Certo et al.
NATURE METHODS (2012)
Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin
Esther Hoste et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Essential Role of the Keratinocyte-Specific Endonuclease DNase1L2 in the Removal of Nuclear DNA from Hair and Nails
Heinz Fischer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
Sulaiman M. Al-Mayouf et al.
NATURE GENETICS (2011)
DNase 2 Is the Main DNA-Degrading Enzyme of the Stratum Corneum
Heinz Fischer et al.
PLOS ONE (2011)
Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions
Yvonne Dombrowski et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Positional differences in the wound transcriptome of skin and oral mucosa
Lin Chen et al.
BMC GENOMICS (2010)
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
Kohki Kawane et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice
David Parra et al.
CANCER RESEARCH (2009)
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa et al.
NATURE (2009)
Epidermal homeostasis: a balancing act of stem cells in the skin
Cedric Blanpain et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential
Nicole Bennardo et al.
PLOS GENETICS (2009)
Trex1 prevents cell-intrinsic initiation of autoimmunity
Daniel B. Stetson et al.
CELL (2008)
Caspase-14 reveals its secrets
Geertrui Denecker et al.
JOURNAL OF CELL BIOLOGY (2008)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
Min Ae Lee-Kirsch et al.
NATURE GENETICS (2007)
DNase1L2 degrades nuclear DNA during corneocyte formation
Heinz Fischer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
Yanick J. Crow et al.
NATURE GENETICS (2006)
Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis
H Fischer et al.
DIFFERENTIATION (2005)
The human TREX2 3′→5′-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis
FW Perrino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The cornified envelope: A model of cell death in the skin
E Candi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Trashing the genome: The role of nucleases during apoptosis
K Samejima et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Gene-targeted mice lacking the Trex1 (DNase III) 3′→5′ DNA exonuclease develop inflammatory myocarditis
M Morita et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Stratum corneum-derived caspase-14 is catalytically active
H Fischer et al.
FEBS LETTERS (2004)
Macrophages require different nucleoside transport systems for proliferation and activation
C Soler et al.
FASEB JOURNAL (2001)
Mutation of DNASE1 in people with systemic lupus erythematosus
K Yasutomo et al.
NATURE GENETICS (2001)
Excision of 3′ termini by the Trex1 and TREX2 3′→5′ exonucleases -: Characterization of the recombinant proteins
DJ Mazur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing
S Lippens et al.
CELL DEATH AND DIFFERENTIATION (2000)
Caspase-14: Analysis of gene structure and mRNA expression during keratinocyte differentiation
L Eckhart et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Features of systemic lupus erythematosus in Dnase1-deficient mice
M Napirei et al.
NATURE GENETICS (2000)