Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-09719-8
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- Tri-Service General Hospital of the National Defense Medical Center, Taiwan [TSGH-C104-024, TSGH-C105-023]
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Serum gamma-glutamyltransferase (gamma-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between gamma-GT and cardiometabolic dysregulation remains unclear in adolescents. We enrolled 7,072 Taiwanese adolescents and followed them for a median of 6.8 years. The optimal cut-off values (CoVs) of baseline gamma-GT to predict future MetS, hypertension (HTN), and type 2 diabetes (T2DM) were determined by receiving operating characteristic (ROC) curve. Using these CoVs, the participants were divided into normal-and high-level groups. Cox proportional hazard analysis was used to calculate hazard ratios (HRs) for the subjects with a high level of gamma-GT for the risk of future cardiometabolic dysregulation. Serum gamma-GT was significantly higher in the subjects with MetS than in those without MetS at baseline (p < 0.001). The optimal CoVs of gamma-GT were 12 U/L for boys and 11 U/L for girls. In multivariate Cox regression analysis, a higher serum gamma-GT level increased the risk of future MetS (HRs 1.98 and 2.85 for boys and girls, respectively, both p < 0.001), but not new onset HTN and T2DM. In conclusion, serum gamma-GT levels not only demonstrated an excellent correlation with the presence of MetS and also in predicting future MetS in adolescents.
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