Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-00533-w
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Funding
- UK Biotechnological and Biological Sciences Research Council (BBSRC) [BB/L020955/1]
- Institute Strategic Programme Grant 'Understanding and Exploiting Plant and Microbial Secondary Metabolism' [BB/J004596/1]
- John Innes Foundation
- Wellcome Trust [090932/Z/09/Z, 094232/Z/10/Z]
- PhD studentship [096685/Z/11/Z]
- Biotechnology and Biological Sciences Research Council [BB/I002294/1, BB/L021250/1, BBS/E/J/00000166, BBS/E/J/000PR9794, BB/L020955/1] Funding Source: researchfish
- BBSRC [BB/L020955/1, BB/L021250/1, BBS/E/J/000PR9794, BB/I002294/1] Funding Source: UKRI
- Wellcome Trust [096685/Z/11/Z] Funding Source: Wellcome Trust
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Cowpea mosaic virus ( CPMV) is a picorna-like plant virus. As well as an intrinsic interest in CPMV as a plant pathogen, CPMV is of major interest in biotechnology applications such as nanotechnology. Here, we report high resolution cryo electron microscopy (cryo-EM) maps of wild type CPMV containing RNA-2, and of naturally-formed empty CPMV capsids. The resolution of these structures is sufficient to visualise large amino acids. We have refined an atomic model for each map and identified an essential amino acid involved in genome encapsidation. This work has furthered our knowledge of Picornavirales genome encapsidation and will assist further work in the development of CPMV as a biotechnological tool.
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