Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-02914-7
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Funding
- UC Davis Food Science Department and College of Agriculture and Environmental Sciences
- Natural Sciences and Engineering Research Council of Canada [482597, RGPIN-2015-04153]
- Eplink Program for Ontario Brain Institute
- NIEHS [R01 ES002710]
- Rapid Assays for Human and Environmental Exposure Assessment
- NIEHS Superfund Research Program [P42 ES004699]
- N.I.H. Pathway to Independence Award [R00 ES024806]
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Linoleic acid (LA; 18: 2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LAderived metabolites accumulate in several rat brain regions during CO2-induced ischemia and that LAderived 13-hydroxyoctadecadienoic acid, but not LA, increase somatic paired-pulse facilitation in rat hippocampus by 80%, suggesting bioactivity. This study provides new evidence that LA participates in the response to ischemia-induced brain injury through oxidized metabolites that regulate neurotransmission. Targeting this pathway may be therapeutically relevant for ischemia-related conditions such as stroke.
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