Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-03231-9
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Funding
- NSFC [31471321]
- National Young 1000 Talents Plan
- Jiangsu Province Recruitment Plan for High-level, Innovative and Entrepreneurial Talents
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All-trans retinoic acid (ATRA), one of vitamin A derivatives, shows greater growth inhibition of breast cancer cell for ER-positive than ER-negative cells, while triple negative breast cancer cell such as MDA-MB-231 cell is poorly responsive to ATRA treatment. In this study, we found that combination of omega-3 free fatty acids (omega-3 FFAs) and ATRA exhibited synergistic inhibition of cell growth in three subtypes (ER+ MCF7, HER2(+) SK-BR-3, Triple negative HCC1806 and MDA-MB-231 cells) of human breast cancer cell lines. The combined treatment of omega-3 FFAs and ATRA resulted in cell cycle arrest. omega-3 FFAs combined with ATRA synergistically provoked cell apoptosis via the caspase signals but not p53. These findings suggest that combined chemotherapy of omega-3 FFAs with ATRA is beneficial for improvement of ATRA sensitivity in breast cancer cells.
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