Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep40104
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- CREST, Japan Science and Technology Agency (JST)
- JST
- Takeda Science Foundation
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Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [N-15, D-14] trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 degrees C, D2O) on its N-15 nuclei and achieves a long retention of the hyperpolarized state. [N-15, D-14] TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by N-15 NMR for over 40 min in phophate-buffered saline (H2O, pH 7.4, 37 degrees C).
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