Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep39805
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Funding
- International Graduate School for Science and Engineering (IGSSE) of the Technische Universitat Munchen (TUM)
- Deutsche Forschungsgemeinschaft
- Center of Integrated Protein Science Munich (CIPSM)
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Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins alpha v beta 3, alpha v beta 5, alpha v beta 6, alpha v beta 8, alpha 5 beta 1, alpha IIb beta 3, using homogenous ELISA-like solid phase binding assay.
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