Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep39676
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Funding
- National Natural Science Foundation of China [21602003]
- EPSRC [EP/I001697/1, EP/G062137/1]
- Engineering and Physical Sciences Research Council [EP/G062137/1, EP/I001697/1] Funding Source: researchfish
- EPSRC [EP/G062137/1, EP/I001697/1] Funding Source: UKRI
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Blood brain-barrier (BBB) in vitro models have been widely reported in studies of the BBB phenotype. However, established co-culture systems involve brain endothelial cells, astrocytes, neurons and pericytes, and therefore are often consuming and technically challenging. Here we use mesenchymal system cells (MSC) as a potential substitute for pericytes in a BBB model. Both MSC and pericyte markers in 2D culture environment were evaluated on different extracellular matrix compositions. Further experiments indicated that MSC contributed in a similar manner to pericytes in a co-cultured 3D model on increasing trans-endothelial electric resistance (TEER) and decreasing permeability against macromolecules.
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