Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep41800
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Funding
- Osteology grant [2008-015]
- KNAW grant [11CDP011]
- Zhejiang Province TCM Science and Technology Plan [2014ZA064]
- Zhejiang Provincial Natural Science Foundation of China [LQ15H140001]
- National Natural Science Foundation of China [81500891]
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Most materials used clinically for filling critical-sized bone defects (CSBD), such as deproteinized bovine bone (DBB), lack osteoinductivity so that their therapeutic effects are far from satisfactory. The effect of bone morphogenic protein 2 (BMP2)-coprecipitated biomimetic calcium phosphate granules (BMP2-cop. BioCaP) on osteoinduction of DBB graft(s) during CSBD healing is still unknown. We investigated whether BMP2-cop. BioCaP affects the osteoinductivity of DBB, bone formation, and foreign body reaction during CSBD healing. DBB + BMP2-cop. BioCaP, DBB, DBB + BMP2, DBB + BioCaP, and autologous bone grafts were implanted in the CSBD of sheep. Bone formation, DBB/BioCaP degradability, foreign body reaction, and osteoinductivity of DBB were analyzed histologically and histomorphometrically at week 4 and 8. Combination of BMP2-cop. BioCaP and DBB healed CSBD as effectively as autologous bone grafts. About 95% of the BMP2-cop. BioCaP had been degraded and replaced by new bone at week 8 in the DBB + BMP2-cop. BioCaP-group. Foreign body reaction was reduced in the DBB + BMP2-cop. BioCaP-group compared to the other groups. The independent use of the BMP2-cop. BioCaP did not achieve a satisfactory bone repair. In conclusion, the BMP2-cop. BioCaP showed good degradability and biocompatibility, and enhanced osteoinductivity of DBB during CSBD healing in sheep, suggesting BMP2-cop. BioCaP as a potential osteoinducer to enhance the therapeutic effects of the graft materials in clinic.
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