Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep38313
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Funding
- University of Franche-Comte
- Region Franche-Comte [RECH-FON12-000013, 2012C-06102]
- France Recherche Nord & Sud Sida-HIV Hepatites (ANRS) [13543, 13544]
- HIVERA (EURECA project)
- Universite Libre de Bruxelles (ULB)
- Belgian Fund for Scientific Research (FRS-FNRS, Belgium)
- NEAT program (European AIDS treatment network)
- Fondation Roi Baudouin (Belgium)
- Wallon region (CIBLES Excellence programm)
- ANRS (France)
- Higher Education Commission, Pakistan
- Belgian 'Fonds pour la Recherche dans l'Industrie et l'Agriculture' (FRIA)
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A latent viral reservoir that resides in resting CD4(+) T cells represents a major barrier for eradication of HIV infection. We test here the impact of HIV protease inhibitor (PI) based combination anti-retroviral therapy (cART) over nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART on HIV-1 reactivation and integration in resting CD4(+) T cells. This is a prospective cohort study of patients with chronic HIV-1 infection treated with conventional cART with an undetectable viremia. We performed a seven-year study of 47 patients with chronic HIV-infection treated with cART regimens and with undetectable plasma HIV-1 RNA levels for at least 1 year. Of these 47 patients treated with cART, 24 were treated with a PI-based regimen and 23 with a NNRTI-based regimen as their most recent treatment for more than one year. We evaluated the HIV-1 reservoir using reactivation assay and integrated HIV-1 DNA, respectively, in resting CD4(+) T cells. Resting CD4(+) T cells isolated from PI-treated patients compared to NNRTI-treated patients showed a limited HIV-1 reactivation upon T-cell stimulation (p = 0.024) and a lower level of HIV-1 integration (p = 0.024). Our study indicates that PI-based cART could be more efficient than NNRTI-based cART for limiting HIV-1 reactivation in aviremic chronically infected patients.
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