Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep29035
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Funding
- Center for Biomedical OCT Research and Translation [P41EB015903]
- National Institutes of Health [R01CA163528, DP2OD008780, R21AI097745, R01HL128168, F32CA183465]
- National Cancer Institute Federal Share of Proton Income
- Swiss National Science Foundation early post-doctoral mobility fellowship [P2SKP2_158640]
- Burroughs Wellcome Fund postdoctoral award
- UNCF-Merck postdoctoral fellowship
- Swiss National Science Foundation (SNF) [P2SKP2_158640] Funding Source: Swiss National Science Foundation (SNF)
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Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical microscopy techniques provide the resolution required for these measurements, but existing optical techniques for measuring lymph flow require complex protocols and provide limited temporal resolution. Here, we describe a Doppler optical coherence tomography platform that allows direct, label-free quantification of lymph velocity and volumetric flow rates. We overcome the challenge of very low scattering by employing a Doppler algorithm that operates on low signal-to-noise measurements. We show that this technique can measure lymph velocity at sufficiently high temporal resolution to resolve the dynamic pulsatile flow in collecting lymphatic vessels.
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