Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep26087
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Funding
- John D. and Catherine T. MacArthur Foundation
- Alfred P. Sloan Foundation
- Army Research Laboratory
- Army Research Office [W911NF-10-2-0022, W911NF-14-1-0679]
- National Institute of Mental Health [2-R01-DC-009209-11]
- National Institute of Child Health and Human Development [1R01HD086888-01]
- Office of Naval Research
- National Science Foundation (CRCNS) [BCS-1441502]
- National Science Foundation (CAREER) [PHY-1554488]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [1430087] Funding Source: National Science Foundation
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The gut microbiome plays a key role in human health, and alterations of the normal gut flora are associated with a variety of distinct disease states. Yet, the natural dependencies between microbes in healthy and diseased individuals remain far from understood. Here we use a network-based approach to characterize microbial co-occurrence in individuals with inflammatory bowel disease (IBD) and healthy (non-IBD control) individuals. We find that microbial networks in patients with IBD differ in both global structure and local connectivity patterns. While a core microbiome is preserved, network topology of other densely interconnected microbe modules is distorted, with potent inflammation-mediating organisms assuming roles as integrative and highly connected inter-modular hubs. We show that while both networks display a rich-club organization, in which a small set of microbes commonly co-occur, the healthy network is more easily disrupted by elimination of a small number of key species. Further investigation of network alterations in disease might offer mechanistic insights into the specific pathogens responsible for microbiome-mediated inflammation in IBD.
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