Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep25258
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Funding
- Microscan B.V. (Amsterdam)
- Gerbrand de Jong Fonds (the Netherlands)
- Dutch Technology Foundation STW (iMIT-Instruments for Minimally Invasive Techniques, project OBAMA)
- Dutch Technology Foundation STW (iMIT-Instruments for Minimally Invasive Techniques, project PROSPECT)
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Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (tau(c)) and blood flow velocity (V), i.e. 1/tau(c) = alpha V. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on the influence of the optical properties of scatterers on alpha in vitro and in vivo. We found a good agreement to theoretical predictions within certain limits for scatterer size and multiple scattering. We present a practical model-based scaling factor to correct for multiple scattering in microcirculatory vessels. Our results show that SDF-LSCI offers a quantitative measure of flow velocity in addition to vessel morphology, enabling the quantification of the clinically relevant blood flow, velocity and tissue perfusion.
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