Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep26795
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Funding
- Medical Research Council (MRC) [U105960371, U123261351, MCA760-5QX00]
- Department for International Development (DFID) under the MRC/DFID Concordat agreement [U105960371, U123261351, MCA760-5QX00]
- MRC [MC_U105960371] Funding Source: UKRI
- Medical Research Council [MC_U105960371] Funding Source: researchfish
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Pregnancy and lactation are associated with changes in vitamin D and calcium metabolism but the impact of these changes on vitamin D expenditure is unknown. We measured plasma 25(OH)D-3 half-life with a stable-isotope tracer and investigated relationships with vitamin D metabolites in pregnant, lactating and 'non-pregnant, non-lactating' (NPNL) women. Vitamin D metabolites, vitamin D binding protein (DBP), PTH and 25(OH)D-3 half-life were measured in third-trimester pregnant women (n22) and repeated during lactation 12 weeks post-partum (n14) and twice in NPNL women (n23 and n10, respectively) in rural Gambia where calcium intakes are low with little seasonality in UVB-exposure. 25(OH)D-3 half-life was not significantly different between groups (mean(SD): 20.6(6.8), 22.6(7.7), 18.0(4.7) and 17.7(9.5) days in pregnant, lactating and NPNL women, respectively). Plasma 25(OH) D3, 1,25(OH)(2)D, and DBP were higher in pregnancy, and calculated free-25(OH)D-3 and PTH were lower (P < 0.05). In lactation, 25(OH)D-3 and 24,25(OH)(2)D-3 were lower compared to pregnant (P < 0.001, P = 0.02) and NPNL women (P = 0.04, P = 0.07). Significant associations were observed between half-life and 25(OH)D-3 (+ ve) in pregnancy, and in all groups between 25(OH)D-3 and free-25(OH)D-3 (+ ve) and PTH and 25(OH)D-3 (-ve) (P < 0.0001). These data suggest that adaptive changes in pregnancy and lactation occur that prevent pronounced changes in vitamin D expenditure.
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