Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep21645
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Funding
- Genus plc
- BBSRC grant [BB/L007371/1]
- BBSRC Institute Strategic Programme (ISP) Grant
- BBSRC [BBS/E/D/05251445, BB/L007371/1, BBS/E/D/05251444, BBS/E/D/05251443, BBS/E/D/20221658, BBS/E/D/05251442] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20221658, 1248012, BBS/E/D/05251444, BB/L026236/1, BB/N015339/1, BB/M028313/1, BBS/E/D/05251442, BBS/E/D/05251445, BB/L007371/1, BBS/E/D/05251443] Funding Source: researchfish
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We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one generation opens unprecedented opportunities for agriculture and basic research.
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