Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep18092
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Funding
- Pfizer
- National Institutes of Health [R01-NS085419, R01-AG044546, P01-AG003991, R01-AG035083]
- Alzheimer Association [NIRG-11-200110]
- New Investigator Award in Alzheimer's disease from the American Federation for Aging Research
- BrightFocus Foundation Alzheimer's Disease Research Grant [A2013359S]
- NIH [P50 AG05681, P01 AG03991, P01 AG026276, U01AG032984]
- GERAD from the Wellcome Trust [GR082604MA]
- Medical Research Council [G0300429]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Rev Health Research
- Hope Center for Neurological Disorders
- Departments of Neurology and Psychiatry at Washington University School of Medicine
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Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genomewide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes, and multiple sclerosis. These data suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits. We found three potential pleiotropic genes: ABO for plasma SELE and ACE levels, FUT2 for CA19-9 and CEA plasma levels, and APOE for ApoE and CRP levels. We also found multiple independent signals in loci associated with plasma levels of ApoH, CA19-9, FetuinA, IL6r, and LPa. Our study highlights the power of biological traits for genetic studies to identify genetic variants influencing clinically relevant traits, potential pleiotropic effects, and complex disease associations in the same locus.
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