Journal
SCIENTIFIC REPORTS
Volume 5, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep08643
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Funding
- Army Research Office of U.S. Department of Defense [W911NF-12-1-0059]
- 973 program
- Ministry of Science and Technology, China [2015CB554202]
- National Natural Science Foundation of China [31170083, 31170082, 31130068]
- Specialized Research Fund for the Doctoral Program of Higher Education, China [20130073110062]
- Department of Homeland Security [2009-ST-062-000018]
- California State University Program for Education and Research in Biotechnology (Entrepreneurial Joint-Venture grant)
- NIH Minority Biomedical Research Support-Research Initiative for Scientific Enhancement (MBRS-RISE) Program [5R25GM061331]
- Army Research Office of U.S. Department of Defense [W911NF-12-1-0059]
- 973 program
- Ministry of Science and Technology, China [2015CB554202]
- National Natural Science Foundation of China [31170083, 31170082, 31130068]
- Specialized Research Fund for the Doctoral Program of Higher Education, China [20130073110062]
- Department of Homeland Security [2009-ST-062-000018]
- California State University Program for Education and Research in Biotechnology (Entrepreneurial Joint-Venture grant)
- NIH Minority Biomedical Research Support-Research Initiative for Scientific Enhancement (MBRS-RISE) Program [5R25GM061331]
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Acinetobacter baumannii is an important human pathogen due to its multi-drug resistance. In this study, the genome of an ST10 outbreak Acinetobacter baumannii isolate LAC-4 was completely sequenced to better understand its epidemiology, antibiotic resistance genetic determinants and potential virulence factors. Compared with 20 other complete genomes of Acinetobacter baumannii, LAC-4 genome harbors at least 12 copies of five distinct insertion sequences. It contains 12 and 14 copies of two novel IS elements, ISAba25 and ISAba26, respectively. Additionally, three novel composite transposons were identified: Tn6250, Tn6251 and Tn6252, two of which contain resistance genes. The antibiotic resistance genetic determinants on the LAC-4 genome correlate well with observed antimicrobial susceptibility patterns. Moreover, twelve genomic islands (GI) were identified in LAC-4 genome. Among them, the 33.4-kb GI12 contains a large number of genes which constitute the K (capsule) locus. LAC-4 harbors several unique putative virulence factor loci. Furthermore, LAC-4 and all 19 other outbreak isolates were found to harbor a heme oxygenase gene (hemO)-containing gene cluster. The sequencing of the first complete genome of an ST10 Acinetobacter baumannii clinical strain should accelerate our understanding of the epidemiology, mechanisms of resistance and virulence of Acinetobacter baumannii.
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