Journal
SCIENTIFIC REPORTS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep06653
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Funding
- NIH-NIEHS Center [P30-ES002109]
- Johnson & Johnson Corporate Office of Science and Technology
- Erik Philip-Sorensen Foundation
- NIH [CA106416]
- Kathy and Curt Marble Cancer Research Fund
- Koch Institute zebrafish core facility
- Nancy Hopkins
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Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
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