Journal
SCIENTIFIC REPORTS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep07115
Keywords
-
Categories
Funding
- MEXT KAKENHI [25116002]
- MEXT, Japan
- Waseda Research Institute for Science and Engineering
- Uehara Foundation
- Naito Foundation
- Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists [25-3931]
- Grants-in-Aid for Scientific Research [26116521, 25116002, 26114715, 24570138] Funding Source: KAKEN
Ask authors/readers for more resources
The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle and reveal its hybrid structure, in which the physical characteristics of CENP-A and H3.3 are conserved independently within the same particle. The CENP-A/H3.3 nucleosome forms an unexpectedly stable structure as compared to the CENP-A nucleosome, and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
