Journal
SCIENTIFIC REPORTS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep05513
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Funding
- 973 project [2013CB733700]
- National Science Fund for Distinguished Young Scholars [81125023]
- National Natural Science Foundation of China [21176076, 21202045, 81173033]
- Key Project of Shanghai Science and Technology Commission [13NM1400900]
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A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.
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