Journal
AGING AND DISEASE
Volume 6, Issue 1, Pages 56-75Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2014.0209
Keywords
aging; cancer; cell cycle; cellular senescence; cell death; cellular signaling
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Funding
- NSERC of Canada
- Concordia University Chair Fund
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Age is the major risk factor in the incidence of cancer, a hyperplastic disease associated with aging. Here, we discuss the complex interplay between mechanisms underlying aging and cancer as a reciprocal relationship. This relationship progresses with organismal age, follows the history of cell proliferation and senescence, is driven by common or antagonistic causes underlying aging and cancer in an age-dependent fashion, and is maintained via age-related convergent and divergent mechanisms. We summarize our knowledge of these mechanisms, outline the most important unanswered questions and suggest directions for future research.
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