Journal
SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep02647
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Funding
- National Natural Science Foundation [21071137, U1232211, 31100992]
- Anhui Province Project [11040606Q54, 08040102005]
- Doctoral Fund of the Ministry of Education of China [20113402130010]
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Nanoprobes with dual modal imaging of magnetic resonance imaging (MRI) and two-photon fluorescence (TPF) can serve as promising platforms for clinical diagnosis. A wide range of molecules and nanoparticles have been investigated as agents for contrast enhanced MRI and fluorescence imaging in cancer diagnosis. However, a single material with dual modal imaging of MRI and TPF is rarely reported. We found that Mn-3[Co(CN)(6)](2) nanocubes can serve as agents for both T-1- and T-2-weighted MRI, and TPF imaging. The nanocubes coated with silica to form Mn-3[Co(CN)(6)](2)@SiO2 core-shell nanocubes were readily internalized by cells without showing cytotoxicity. In vitro tests, the core-shell nanocubes display relatively high longitudinal (r(1)) and transverse (r(2)) relaxivities, they also manifest a remarkable T-1 and T-2 contrast effects at in-vivo imaging of internal organs in Mice. Moreover, the core-shell nanocubes could offer high-resolution cell fluorescence imaging by two-photon excitation (720 nm) or by conventional fluorescence with 403- or 488-nm excitation.
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