4.7 Article

Computed tomography imaging-guided radiotherapy by targeting upconversion nanocubes with significant imaging and radiosensitization enhancements

Journal

SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/srep01751

Keywords

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Funding

  1. National Natural Science Foundation of China [50823007, 50972154, 51132009, 51072212, 21172043, 51102259]
  2. Shanghai Rising Star Program [12QH1402500]
  3. Nano special program of the Science and Technology Commission of Shanghai [11nm0505000, 124119a0400]
  4. Development Foundation for Talents of Shanghai [2012035]
  5. National Basic Research Program of China (973 Program) [2011CB707905]
  6. China National Funds for Distinguished Young Scientists [51225202]
  7. Young Investigator Fund of Fudan University [EYF163006]

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The clinical potentials of radiotherapy could not be achieved completely because of the inaccurate positioning and inherent radioresistance of tumours. In this study, a novel active-targeting upconversion theranostic agent (arginine-glycine-aspartic acid-labelled BaYbF5:2% Er3+ nanocube) was developed for the first time to address these clinical demands. Heavy metal-based nanocubes (similar to 10 nm) are potential theranostic agents with bifunctional features: computed tomography (CT) contrast agents for targeted tumour imaging and irradiation dose enhancers in tumours during radiotherapy. Remarkably, they showed low toxicity and excellent performance in active-targeting CT imaging and CT imaging-guided radiosensitizing therapy, which could greatly concentrate and enlarge the irradiation dose deposition in tumours to enhance therapeutic efficacy and minimize the damage to surrounding tissues.

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