Journal
SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01514
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- Max Planck Society
- DFG [SCHW 1578/1-1]
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gamma-protocadherins (gamma-pcdhs) are transmembrane receptor proteins ubiquitously expressed in the postnatal and adult mouse brain. gamma-pcdhs are required for normal neuronal development as shown for spinal cord interneurons, retinal ganglion cells and cortical neurons. To test the role of gamma-pcdhs during development of subventricular zone progenitor cells and their subsequent differentiation into olfactory granule cells we generated a conditional gamma-pcdh(lox/lox) allele(gamma-pcdh(lox/lox)) allowing for functional gamma-pcdh inactivation upon lentivirus-mediated Cre-recombinase expression selectively in subventricular zone progenitor cells. While gamma-pcdh loss did not alter the proliferation of subventricular zone progenitors, gamma-pcdh ko progenitors that reached the main olfactory bulb showed a significant reduction in dendritic arborization and failed to develop dendritic spines. Our results suggest that olfactory bulb granule cell maturation necessitates functional gamma-pcdh expression.
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