Journal
SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01104
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Funding
- Japan Society for the Promotion of Science [22790040]
- Ministry of Health Labour and Welfare [24100701]
- Grants-in-Aid for Scientific Research [22790040] Funding Source: KAKEN
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To obtain a tumor cell-selectivity of methyl-beta-cyclodextrin (M-beta-CyD), we newly synthesized folate-appended M-beta-CyD (FA-M-beta-CyD), and evaluated the potential of FA-M-beta-CyD as a novel anticancer agent in vitro and in vivo. Potent antitumor activity and cellular association of FA-M-beta-CyD were higher than those of M-beta-CyD in KB cells, folate receptor (FR)-positive cells. FA-M-beta-CyD drastically inhibited the tumor growth after intratumoral or intravenous injection to FR-positive Colon-26 cells-bearing mice. The antitumor activity of FA-M-beta-CyD was comparable and superior to that of doxorubicin after both intratumoral and intravenous administrations, respectively, at the same dose, in the tumor-bearing mice. All of the tumor-bearing mice after an intravenous injection of FA-M-beta-CyD survived for at least more than 140 days. Importantly, an intravenous administration of FA-M-beta-CyD to tumor-bearing mice did not show any significant change in blood chemistry values. These results strongly suggest that FA-M-beta-CyD has the potential as a novel anticancer agent.
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