Journal
SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01293
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Funding
- National Institute of Health (NIH) [R01CA44114]
- National Science Foundation (NSF) [DBI-0852737]
- Department of Defense (DoD) [W81XWH-11-1-0123]
- NSF [CMMI-1235100]
- Arkansas Biosciences Institute
- China Scholarship Council (CSC) [2010665505]
- [R01EB000873]
- [R01CA131164]
- [R01EB009230]
- [R21CA139373]
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0852737] Funding Source: National Science Foundation
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Nanotechnology has been extensively explored for drug delivery. Here, we introduce the concept of a nanodrug based on synergy of photothermally-activated physical and biological effects in nanoparticle-drug conjugates. To prove this concept, we utilized tumor necrosis factor-alpha coated gold nanospheres (Au-TNF) heated by laser pulses. To enhance photothermal efficiency in near-infrared window of tissue transparency we explored slightly ellipsoidal nanoparticles, its clustering, and laser-induced nonlinear dynamic phenomena leading to amplification and spectral sharpening of photothermal and photoacoustic resonances red-shifted relatively to linear plasmonic resonances. Using a murine carcinoma model, we demonstrated higher therapy efficacy of Au-TNF conjugates compared to laser and Au-TNF alone or laser with TNF-free gold nanospheres. The photothermal activation of low toxicity Au-TNF conjugates, which are in phase II trials in humans, with a laser approved for medical applications opens new avenues in the development of clinically relevant nanodrugs with synergistic antitumor theranostic action.
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