Journal
SCIENTIFIC REPORTS
Volume 3, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01224
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Funding
- Ministry of Education, Science, Sports and Culture of Japan
- Knowledge Cluster Initiative (Stage-2) Research Foundation
- Takeda Science Foundation
- Sumitomo Foundation
- NIH [NS41030, HD47380]
- Japan Society for the Promotion of Science (JSPS) [22390056]
- Adaptable and Seamless Technology Transfer Program (A-STEP) through Target-driven R&D, Japan Science and Technology Agency [AS231Z02224G]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [11001981]
- Uehara Memorial Foundation
- KAKENHI from the Ministry of Education, Science, Sports and Culture of Japan (MEXT) of Japan [16680015, 21300121, 21390069, 19653081]
- Neuroinformatics Japan Center (NIJC)
- CREST of Japan Science and Technology Agency (JST)
- Funding Program for Next Generation World-Leading Researchers (Next Program)
- Multidisciplinary program for elucidating the brain development from molecules to social behavior (Fukui Brain Project)
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [24111546, 24700352, 21390069, 21300121, 25460399, 22390056, 24113007, 23659092] Funding Source: KAKEN
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Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1(+/-) mice, impaired behavioral performance and improvement of F-18-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1(+/-) mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.
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