Journal
SCIENCE IN CHINA SERIES B-CHEMISTRY
Volume 52, Issue 4, Pages 402-414Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-009-0029-8
Keywords
artificial nuclease; DNA cleavage; metal-free cleavage DNA; guanidinium group; aza-crown ether
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The design of artificial nucleases and nuclease mimics has attracted extensive attention and made great progress due to their significant scientific meanings and potential application in the field of gene medicine and molecular biology. This paper reviews recent progress in the investigation of artificial nuclease, including bifunctional cooperative catalysis, dinuclear synergistic catalysis, metal-free catalysis, and especially, the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.
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