Journal
RSC ADVANCES
Volume 4, Issue 87, Pages 46666-46674Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra07954j
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Funding
- Hungarian Research Foundation [OTKA NK81371, PD103994]
- European Union
- State of Hungary - European Social Fund
- Hungarian Academy of Sciences
- Hungarian Academy of Sciences [LP2012-48/2012]
- OTKA-NKTH [CK80763]
- [TAMOP-4.2.2/A-11/1/KONV-2012-0035]
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A flow chemistry-based technique is presented herein for Cu(I)-catalyzed azide-alkyne cycloadditions with a copper on iron bimetallic system as the catalyst and iron powder as a readily available copper scavenger. The method proved to be rapid and safe as compared with the conventional batch experiment; and by using an in-line copper scavenger, the level of copper impurities in the triazole products could readily be reduced to negligibly small amounts. The process was widely applicable, as not only terminal alkynes, but also various disubstituted acetylenes were nicely tolerated as dipolarophiles leading to useful 1,4,5-trisubstituted 1,2,3-triazoles.
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