Journal
RSC ADVANCES
Volume 4, Issue 64, Pages 33986-33997Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra03993a
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Funding
- National Natural Science Foundation of China [21175134, 21375125]
- Creative Research Group Project of National Natural Science Foundation of China [21321064]
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Chemo-photothermal therapy with the combination of chemotherapy and photothermal therapy has emerged as a promising anticancer treatment for its synergistic effects. In this work, the functionalized mesoporous carbon nanoparticles (FA/PEI/O-MCN) were constructed by modifying the mesoporous carbon nanoparticles (MCN) with polyethylenimine (PEI) and folic acid (FA) for the targeted chemophotothermal therapy. The FA/PEI/O-MCN exhibited strong light absorption and high photothermal conversion efficiency in the near-infrared (NIR) region due to the graphitic structure of MCN. Meanwhile, FA/PEI/O-MCN displayed high drug loading capacity using doxorubicin hydrochloride (DOX) as a model drug. Flow cytometry analysis and competitive binding experiments verified that the FA modification could significantly enhance the uptake of FA/PEI/O-MCN by HeLa cells with folate receptors (FR) over-expressing. Comparing with chemotherapy or photothermal therapy alone, the DOX-loaded FA/PEI/OMCN demonstrated the synergistic effects and resulted in the higher therapeutic efficacy. We believe that the FA/PEI/O-MCN could be applied as an efficient chemo-photothermal platform to realize the targeted synergistic therapy.
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