4.6 Article

A ratiometric fluorescent probe for highly selective and sensitive detection of hypochlorite based on the oxidation of N-alkylpyridinium

Journal

RSC ADVANCES
Volume 4, Issue 103, Pages 59535-59540

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra10633d

Keywords

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Funding

  1. National Natural Science Foundation of China [21202063, 21105038]
  2. Ministry of Science and Technology of China for the International Science Linkages Program [2011DFG52970]
  3. Ministry of Education of China for Changjiang Innovation Research Team [IRT1064]
  4. Natural Science Foundation of Jiangsu Province [BK2012281]
  5. Jiangsu Innovation Research Team
  6. Research Foundation of Jiangsu University [11JDG078]

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A simple and efficient ratiometric fluorescent probe 1 for hypochlorite has been rationally constructed based on a novel hypochlorite promoted oxidation of N-alkylpyridinium reaction. Notably, this oxidation reaction was first employed for developing fluorescent hypochlorite probe. Upon addition of hypochlorite, probe 1 presented a ratiometric response, with the emission wavelength displaying a remarkable blue shift (up to 143 nm). Probe 1 also provided highly selective and sensitive response to hypochlorite. The detection limit was measured to be 0.093 mu M. The sensing reaction product, compound 2, was isolated and confirmed by NMR spectra and mass spectrometry. TD-DFT calculation demonstrated that the intramolecular charge transfer process in compound 2 was significantly inhibited, which result in the large blue shift of emission. Probe 1 has been successfully applied for hypochlorite detection in natural water samples. Living cell imaging experiments established that probe 1 could detect not only artificially loaded but also endogenous hypochlorite in living cells.

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