Journal
RSC ADVANCES
Volume 4, Issue 53, Pages 28072-28077Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra04851b
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Funding
- Engineering and Physical Sciences Research Council
- GlaxoSmithKline
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Reaction of 2-chloropyrazine and 2-chloropyrimidine with phenols and alcohols in the presence of K2CO3 in DMSO results in high yielding SNAr coupling. The reaction works particularly well with phenols and yields are comparable or superior to the metal-catalysed couplings described in the literature.
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