Journal
RSC ADVANCES
Volume 4, Issue 93, Pages 51548-51557Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra07860h
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Funding
- Program for the National Natural Science Foundation of China [21272214]
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The asymmetric domino reaction of various 3-nitro-2H-chromene derivatives 2 to 3-isothiocyanato oxindole 3 with moderate to good enantioselectivities, employing readily available bifunctional thiourea 1d as the organocatalyst, was described. A series of chiral multi-functionalized tetracyclic spiro [chromeno[3,4-c] pyrrole-1,3'-indoline] derivatives with four vicinal chiral carbon centers including two quaternary stereocenters were successfully prepared. Notably, the products 5 could be cleanly converted to the compounds 4 in ethanol under mild conditions.
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