4.6 Article

Lumazine synthase protein cage nanoparticles as modular delivery platforms for targeted drug delivery

Journal

RSC ADVANCES
Volume 4, Issue 89, Pages 48596-48600

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra10187a

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Funding

  1. National Research Foundation of Korea (NRF) - Korean government [NRF-2013R1A1A1008228]
  2. Collaborative Research Program for Convergence Technology of the Korea (KRCF) [Seed-11-6]
  3. UNIST [1.140028.01]
  4. National Research Council of Science & Technology (NST), Republic of Korea [Seed-11-6] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  5. National Research Foundation of Korea [2013R1A1A1008228, 22A20130012280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Lumazine synthase protein cage nanoparticle isolated from Aquifex aeolicus (AaLS) is developed as a modular delivery nanoplatform that genetically acquires either tumor vasculature targeting peptides or hepatocellular carcinoma cell surface targeting peptides on its surface. The targeting peptide bearing AaLS effectively delivers its cargo to their target cancer cells.

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