Journal
RSC ADVANCES
Volume 4, Issue 96, Pages 53864-53869Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra06416j
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Funding
- NSFC [21471042, 21101049]
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The synthesis and characterization of a novel NIR region fluoride sensor, that makes use of the aza-boron-dipyrromethene (aza-BODIPY) fluorophore, is described. An arylmagnesium bromide was formed by reacting 4-bromophenol with a tert-butyldimethylsilyl protecting group and magnesium, which was then used to prepare the aza-BODIPY through a reaction with phthalonitrile. The unusually strong affinity between the fluoride anion and silicon is used to create a sensor dye, which exhibits a highly specific, rapid colorimetric and 'turn-off' fluorescence response for F- in solution and in living HeLa cells. With F-, there is enhanced intramolecular charge transfer within the S-1 state and this results in efficient nonradiative decay and hence in a marked decrease in fluorescence emission intensity.
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