Journal
RSC ADVANCES
Volume 4, Issue 8, Pages 3758-3767Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra45850d
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
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An efficient greener approach for the one-pot four-component synthesis of dihydropyridines has been developed utilizing L-proline as a base catalyst under solvent-free conditions. This domino reaction involves Huisgen dipolar additions using amines and activated alkynes for the formation of novel dihydropyridines. The synthesized dihydropyridines were subjected to acid treatment which resulted in the selective formation of dihydropyridinones as a single diastereomer.
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