4.6 Article

Nano graphene oxide-hyaluronic acid conjugate for target specific cancer drug delivery

Journal

RSC ADVANCES
Volume 4, Issue 27, Pages 14197-14200

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra00605d

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Funding

  1. Converging Research Center Program through the National Research Foundation of Korea (NRF)
  2. Ministry of Education, Science and Technology [2009-0081871]
  3. Mid-career Researcher Program through NRF
  4. MEST [2012R1A2 A2A06045773]

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A nano graphene oxide-hyaluronic acid (NGO-HA) conjugate was successfully prepared for target specific delivery of an anti-cancer drug loaded by pi-pi stacking via HA receptor mediated endocytosis. In vitro tests confirmed the pH dependent drug release and target specific anti-cancer effect of the complex.

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