Journal
RSC ADVANCES
Volume 4, Issue 52, Pages 27286-27289Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra04824e
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The first direct asymmetric vinylogous Mannich reaction of gamma-butenolides with isatin-derived ketimines has been effectively realized promoted by a bifunctional quinidine-derived catalyst. A series of chiral 3-aminooxindole derivatives bearing adjacent tertiary and quaternary stereocenters with the butenolide moiety were obtained in excellent yields (up to 97%) and high enantioselectivities (up to 96% ee).
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