Journal
RSC ADVANCES
Volume 4, Issue 16, Pages 8191-8199Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra47453d
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Funding
- Natural Science Foundation Committee of China (NSFC) [81371684, 81000666, 81220108012, 61335007, 81171395, 81328012]
- New Century Excellent Talents (NCET) in University of the Ministry of Education of China
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The unique properties of gold nanoclusters (Au NCs) enable them to be functionalized as fluorescent probes or pro-drugs for biomedical application. A facile approach was introduced to synthesize nanoconjugates (Au-cRGD-MPA), which was composed of Au NCs, cyclic (Arg-Gly-Asp-DTyr-Lys) (cRGD) peptide and a near infrared (NIR) fluorescence dye (MPA). The nanoconjugates exhibited dual fluorescence in the visible range and NIR range simultaneously. The low cytotoxicity of Au-cRGD-MPA was demonstrated in MCF-7 cell line and U87 cell line. The cell affinity investigations verified the outstanding tumor-targeting capability of Au-cRGD-MPA for tumor cells. The biodistribution characteristics and tumor targeting ability of the probes were elucidated in normal nude mice and tumor-bearing mice, respectively. Attributing to the small size (less than 5 nm), the majority of the nanoconjugates metabolized from the living subjects via the kidney-bladder pathway. Additionally, Au-cRGD-MPA displayed favorable tumor-specificity in Integrin alpha(v)beta(3) over-expressed tumor-bearing (MDA-MB-231) mice. Consequently, the results demonstrated that the dual fluorescence probe is a promising candidate for tumor imaging and disease treatment monitoring.
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