4.6 Article

Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

Journal

RSC ADVANCES
Volume 4, Issue 21, Pages 10875-10878

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra00701h

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB833300]
  2. National Natural Science Foundation of China [21025209, 21121062, 21332009]

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A highly efficient synthesis of N-allylindoles was realized via palladium-catalyzed asymmetric allylic amination/oxidation sequential reaction of indolines. The N-alkylated indole derivatives were obtained with up to 91% yield and 97% ee.

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