4.6 Article

Pd-catalyzed ligand-free Suzuki reaction of β-substituted allylic halides with arylboronic acids in water

Journal

RSC ADVANCES
Volume 4, Issue 22, Pages 11152-11158

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra47813k

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Funding

  1. National Natural Science Foundation of China [21072225, 21172258, 21372258, 91127039]

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The catalyst system consisting of Pd(TFA)(2) and KOH allows for a wide range of beta-substituted allylic halides to react efficiently with various arylboronic acids in neat water under ligand-free conditions, affording the allylated arenes in high yields with broad functional group tolerance and up to 7.4 x 10(5) TON and 15 416 h(-1) TOF.

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