4.6 Article

A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

Journal

RSC ADVANCES
Volume 4, Issue 22, Pages 11417-11419

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra47210h

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Funding

  1. CSIR, INDIA
  2. ORIGIN

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The key synthon cis-aziridine has been efficiently utilised for the synthesis of oseltamivir phosphate, using Wittig olefination, Barbier addition, Mitsunobu reaction and ring closing metathesis (RCM) as key essentials.

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