Journal
RSC ADVANCES
Volume 4, Issue 43, Pages 22542-22544Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra03806a
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- BBSRC
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The human copper metallochaperone (CCS) for Cu, Zn-superoxide dismutase (SOD1) has a similar Zn(II) site as that in SOD1. Dimeric CCS converts to a monomer in the reduced Zn(II)-depleted form that weakens the interaction with SOD1. This form of CCS may be fibril-logenic and disease causing, as is the case for demetallated and reduced monomeric SOD1.
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